Total synthesis of cadalen-15-oic acid
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چکیده
منابع مشابه
Total Synthesis of (±)-Actinophyllic Acid
The first total synthesis of (+/-)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope-Mannich rearrangement that assembled the core structure of the natural product's unique ring system. The synthesis was accomplished from di-tert-butyl malonate in 8% overall yield by a concise sequenc...
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A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the B ring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.
متن کاملTotal synthesis of (+/-)-nudenoic acid.
In 1968, Marshall and Johnson settled a long-standing structural problem with â-vetivone, firmly establishing it as 1 by synthesis.1 Previously, â-vetivone was considered to be a bicyclic R,â-unsaturated ketone possessing a hydrazulene framework, interpretive of its dehydrogenation to give vetivazulene. The interpretive error arose from the assumption that the dehydrogenation occurred without s...
متن کامل3α-Hydroxytirucalla-8,24-dien-21-oic acid
The title compound, C(30)H(48)O(3), a triterpene isolated from the resin of canarium schweinfurthiiand, is an isomer of the previously reported triterpene 3α-hy-droxy-tirucalla-7,24-dien-21-oic acid [Mora et al. (2001 ▶). Acta Cryst. C57, 638-640], which crystallizes in the same trigonal space group. The title mol-ecule consists of four fused rings having chair, half-chair, half-chair and envel...
متن کاملTotal synthesis of (-)-pseudolaric acid B.
We report a full account of our work toward the total synthesis of pseudolaric acid B (1a), a diterpene acid isolated from the bark of Pseudolarix kaempferi Gordon (pinaceae). Compound 1a is an antifungal and antifertility agent. Furthermore, its capacity for inhibiting tubulin polymerization makes it a potential lead for cancer therapy. Herein, we describe the use of a Ru- or Rh-catalyzed [5 +...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2009
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0010.d09